Treatment of non-gonococcal urethritis with sigmamycin. A controlled method of investigation.
نویسنده
چکیده
Sigmamycin is a 2 :1 combination of the antibiotics tetracycline hydrochloride and oleandomycin phosphate, and the claim has been made that this combination exhibits a synergistic action, so that the two drugs together are more potent than the sum of the individual components. To test this claim two separate trial series of patients were treated, using a small dose for a minimum time in the first, and a large dose for a slightly longer period in the second. In each series controls were used and the drug or a placebo was administered by the double-blind method to a total of 200 white male patients with non-gonococcal urethritis. Neither patients nor medical staff knew who received antibiotic or placebo, and the key to the coding used was retained by the suppliers of the drug until the completion of each half of the trial.
منابع مشابه
Residual non-gonococcal urethritis: P.A.M. and sulphathiazole in the treatment of gonorrhea.
The spectacular success of penicillin in the treatment of acute gonococcal urethritis, the disappearance of dysuria in a matter of hours, the cessation of a profuse discharge in less than a day, the elimination of gonococci overnight, and the virtual absence of gonococcal relapse when a depot preparation is given in adequate dosage, has focused attention on one of the remaining problems in the ...
متن کامل[Diagnosis of gonococcal urethritis and chlamydial urethritis by polymerase chain reaction].
A polymerase chain reaction (PCR) method was compared to standard methods (cultures for Neisseria gonorrhoeae and Chlamydia trachomatis and an enzyme-immunoassay for C. trachomatis) in diagnosis of gonococcal and chlamydial urethritis in 40 male patients with urethritis. Gonococcal urethritis was diagnosed by detection of a 206 bp DNA fragment amplified by PCR with N. gonorrhoeae-specific prime...
متن کاملNon-gonococcal urethritis in the male treated with tetracycline.
The Report of the Chief Medical Officer of the Ministry of Health for 1955 (Ministry of Health, 1956) states that the number of cases of nongonococcal urethritis in male patients increased during that year to a total of 14,269, and that the incidence of this condition exceeded that of gonorrhoea (14,079 cases). For this reason, and because the treatment of non-gonococcal urethritis has in the p...
متن کاملIncidence of Non-Gonococcal Infection in Childbearing and Pregnant Women in Ardabil
Non-gonococcal infections causes are made up of Chlamydia trachomatis (one of the most common infection Non-Gonococcal), Ureaplasma urealyticum (a possible causal in acute pyelonephritis, pelvic inflammatory disease, curiuamniutis, bacterial vaginosis, preterm birth, Non-Gonococcal urethritis, miscarriage, infertility and spontaneous abortion), Gardnerella vaginalis and Streptococcus agalactiae...
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ورودعنوان ژورنال:
- The British journal of venereal diseases
دوره 35 شماره
صفحات -
تاریخ انتشار 1959