Treatment of non-gonococcal urethritis with sigmamycin. A controlled method of investigation.

نویسنده

  • W LEACH
چکیده

Sigmamycin is a 2 :1 combination of the antibiotics tetracycline hydrochloride and oleandomycin phosphate, and the claim has been made that this combination exhibits a synergistic action, so that the two drugs together are more potent than the sum of the individual components. To test this claim two separate trial series of patients were treated, using a small dose for a minimum time in the first, and a large dose for a slightly longer period in the second. In each series controls were used and the drug or a placebo was administered by the double-blind method to a total of 200 white male patients with non-gonococcal urethritis. Neither patients nor medical staff knew who received antibiotic or placebo, and the key to the coding used was retained by the suppliers of the drug until the completion of each half of the trial.

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عنوان ژورنال:
  • The British journal of venereal diseases

دوره 35  شماره 

صفحات  -

تاریخ انتشار 1959